The V1a vasopressin receptor is necessary and sufficient for normal social recognition: A gene replacement study
The V1a vasopressin receptor is necessary and sufficient for normal social recognition: A gene replacement study
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DOI：
10.1016/j.neuron.2005.06.031
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发表时间：
2005-08-18
期刊：
影响因子：
16.2
通讯作者：
Young, LJ
中科院分区：
文献类型：
--
作者：
Bielsky, IF;Hu, SB;Young, LJ
加压素调节许多社会和非社会行为，包括情绪。我们以前曾报道，V1a受体（V1aR）无效突变的雄性小鼠表现出严重的社会认知障碍和焦虑样行为的变化。使用V1aR特异性拮抗剂的位点特异性注射，我们证明了外侧隔，而不是内侧杏仁核，是社会认可的关键。使用病毒载体在V1aR敲除小鼠（V1aRKO）的外侧隔中重新表达V1aR导致了社会识别的完全拯救。此外，V1aR在野生型（WT）小鼠的外侧隔中的过表达导致了社会识别行为的增强和焦虑相关行为的轻度增加。这些结果表明，在外侧隔V1aR在复杂的社会行为所需的社会刺激的神经处理中起着关键作用。
Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.