Abundance of triacylglycerols in ganglia and their depletion in diabetic mice: implications for the role of altered triacylglycerols in diabetic neuropathy
Abundance of triacylglycerols in ganglia and their depletion in diabetic mice: implications for the role of altered triacylglycerols in diabetic neuropathy
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DOI：
10.1111/j.1471-4159.2006.03794.x
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发表时间：
2006-06-01
影响因子：
4.7
通讯作者：
Han, Xianlin
中科院分区：
文献类型：
--
作者：
Cheng, Hua;Guan, Shaoping;Han, Xianlin
在此，我们报告了首次对神经节中丰富的三酰甘油（TAG）的质量分布和分子种类组成的研究。这项研究展示了五项新颖的发现。首先，在多个物种（例如小鼠、大鼠和兔子）的所有检查神经节中都存在意想不到的高水平 TAG。其次，神经节标签海量内容是位置相关的。第三，神经节中的 TAG 质量水平具有物种特异性。第四，链脲佐菌素诱导的糖尿病小鼠的背根神经节 TAG 质量水平相对于未经治疗的对照小鼠显着减少。第五，尽管分子种类组成没有改变，但小鼠神经节 TAG 质量水平随着年龄的增长而降低。总的来说，这些结果表明 TAG 是神经节的重要组成部分，可能导致糖尿病神经病变中周围神经元功能的病理改变。
Herein, we report the first study on the mass distribution and molecular species composition of abundant triacylglycerols (TAG) in ganglia. This study demonstrates five novel findings. First, unanticipated high levels of TAG were present in all examined ganglia from multiple species (e.g. mouse, rat and rabbit). Second, ganglial TAG mass content is location-dependent. Third, the TAG mass levels in ganglia are species-specific. Fourth, dorsal root ganglial TAG mass levels in streptozotocin-induced diabetic mice are dramatically depleted relative to those found in untreated control mice. Fifth, mouse ganglial TAG mass levels decrease with age although molecular species composition is not changed. Collectively, these results indicate that TAG is an important component of ganglia and may potentially contribute to pathological alterations in peripheral neuronal function in diabetic neuropathy.