Burkholderia cenocepacia and Burkholderia multivorans:: influence on survival in cystic fibrosis
Burkholderia cenocepacia and Burkholderia multivorans:: influence on survival in cystic fibrosis
复制标题
DOI：
10.1136/thx.2003.017210
复制
发表时间：
2004-11-01
期刊：
影响因子：
10
通讯作者：
Webb, AK
中科院分区：
文献类型：
--
作者：
Jones, AM;Dodd, ME;Webb, AK
洋葱伯克霍尔德菌感染与囊性纤维化（CF）患者预后不良相关。现在认识到，被归类为洋葱芽孢杆菌的生物包括许多不同的基因组物种，每个物种都被称为洋葱芽孢杆菌复合体（BCC）的基因组变体。个体基因组变异的CF患者感染的结果尚不清楚。1982年至2003年间，在一家CF专科中心研究了感染两种最常见分离的基因组变体（B cenocepacia和B multivorans）的临床结果。方法：对从初始感染进展为慢性感染的患者数量进行评估。将慢性BCC感染患者与铜绿假单胞菌感染患者按1秒用力呼气量百分比进行匹配，建立对照组。结果测量是生存时间、“洋葱增生综合征”的死亡、肺活量测定和体重指数（BMI）的下降率以及治疗要求。结果：49例患者初始感染多形体B （n=16）或新脑结核B (n=33)；8/16和31/33分别发生慢性感染(p
Introduction: Burkholderia cepacia infection has been associated with a poor prognosis for patients with cystic fibrosis (CF). It is now recognised that organisms classified as B cepacia comprise a number of distinct genomic species each known as a genomovar of the B cepacia complex (BCC). The outcome of infection for CF patients with individual genomovars is unknown. The clinical outcome of infection with the two most commonly isolated genomovars (B cenocepacia and B multivorans) was studied at a specialist CF centre between 1982 and 2003.Methods: The numbers of patients who progressed from initial to chronic infection were assessed. Control groups were created by matching patients with chronic BCC infection by percentage forced expiratory volume in 1 second with patients with Pseudomonas aeruginosa infection. Outcome measures were survival time, deaths from "cepacia syndrome'', rate of decline in spirometry and body mass index (BMI), and treatment requirements.Results: Forty nine patients had an initial infection with either B multivorans (n=16) or B cenocepacia (n=33); 8/16 and 31/33, respectively, developed chronic infection (p