Squamous cell carcinoma of buccal mucosa: An analysis of prognostic factors.
Squamous cell carcinoma of buccal mucosa: An analysis of prognostic factors.
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DOI：
10.4103/sajc.sajc_317_16
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发表时间：
2018-01
影响因子：
0.5
通讯作者：
Balasubramaniam G
中科院分区：
文献类型：
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作者：
Bobdey S;Sathwara J;Jain A;Saoba S;Balasubramaniam G
颊粘膜癌是印度次大陆最常见的口腔癌。本研究的目的是分析手术治疗颊粘膜鳞状细胞癌（BMSCC）患者的结果并评估预后因素。回顾性研究通过回顾2006年1月1日至2008年12月31日在塔塔纪念医院诊断和手术治疗的409例病理证实的颊粘膜癌患者的病历进行。队列的总体5年生存率为54.1%。肿瘤、淋巴结、转移（TNM）I、II、III和IV期患者的分期生存率分别为85.2%、82.9%、56.3%和42.6%（P < 0.00）。多变量考克斯比例风险分析发现，合并症的存在、组织学肿瘤大小、病理淋巴结状态、肿瘤分化、神经周围浸润和囊外扩散与总生存率独立相关。BMSCC是一种侵袭性恶性肿瘤。除TNM分期外，其他临床和病理因素也对BMSCC的诊断有重要影响。因此，有必要超越TNM，并开发一个更具包容性，灵活性和易于使用的预后系统。
Carcinoma of the buccal mucosa is the most common oral cavity cancer in the Indian subcontinent. The aim of this study was to analyze the outcome and evaluate prognostic factors in surgically treated buccal mucosa squamous cell carcinoma (BMSCC) patients. A retrospective study was performed by reviewing the medical records of 409 pathologically proven buccal mucosa cancer patients, who were diagnosed and surgically treated in Tata Memorial Hospital between January 1, 2006, and December 31, 2008. The overall 5-year survival of the cohort was found to be 54.1%. The stage-wise survival rate for tumor, node, metastasis (TNM) Stage I, II, III, and IV patients was found to be 85.2%, 82.9%, 56.3%, and 42.6% (P < 0.00), respectively. On multivariate Cox proportional hazard analysis, the presence of comorbidity, histological tumor size, pathological lymph node status, tumor differentiation, perineural invasion, and extracapsular spread were found to be independently associated with overall survival. BMSCC is an aggressive malignant tumor. In addition to TNM classification, other clinical and pathological factors also have a significant role in BMSCC prognostication. Hence, there is a need to move beyond TNM and develop a more inclusive, flexible, and easy to use prognostic system.