CRITICAL PERIODS IN THE DEVELOPMENT OF THE CAENORHABDITIS-ELEGANS DAUER LARVA
CRITICAL PERIODS IN THE DEVELOPMENT OF THE CAENORHABDITIS-ELEGANS DAUER LARVA
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DOI：
10.1016/0012-1606(81)90367-5
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
RIDDLE, DL
中科院分区：
文献类型：
--
作者：
SWANSON, MM;RIDDLE, DL
The dauer larva of C. elegnas is a developmentally arrested stage formed at the 2nd molt under conditions of starvation or overcrowding. It is specialized for long-term survival and dispersal. Dauer-constitutive (daf) mutants form dauer larvae even in an environment favorable for growth. Temperature-sensitive (ts) mutants representing 6 different genes were subjected to temperature-shift and -pulse experiments in order to define the times of temperature sensitivity (TSP). The results for 5 of the mutants, including 1 mutant with a maternal effect, show TSP which bracket the 1st molt. The exceptional mutant, daf-14, has its TSP within the 1st larval stage. The TSP of 2 mutants, daf-8 and daf-14, exhibit distinct major and minor phases. Temperature-pulse experiments discriminate between alternate interpretation of the temperature-shift data. All the results can be interpreted on the basis of normal and defective execution stages for the ts functions at permissive and restrictive temperatures.
