Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor
Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor
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DOI：
10.2337/diacare.29.1.44
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发表时间：
2006-01-01
期刊：
影响因子：
16.2
通讯作者：
Jovanovic, L
中科院分区：
文献类型：
--
作者：
Garg, S;Zisser, H;Jovanovic, L
目的 - 低血糖和血糖大幅波动仍然是胰岛素治疗糖尿病患者实现 HbA(1c) 目标值以及减少相关长期并发症（和经济成本）的主要障碍。在这项研究中，我们评估了连续葡萄糖传感装置的准确性、安全性和临床有效性。 研究设计和方法 - 共有 91 名需要胰岛素的 1 型 (n = 75) 和 2 型 (n = 16) 糖尿病患者参加了这项多中心随机研究。受试者连续三个 72 小时佩戴经皮、为期 3 天的连续葡萄糖传感系统。受试者被随机分配（1:1 比例）到对照组（未提供连续血糖数据）或显示组（在第 1 阶段未提供连续血糖数据，但在第 2 阶段和第 3 阶段显示）。在第 2 和第 3 阶段，显示组中的患者可以实时访问传感器葡萄糖值，可以查看之前 1、3 和 9 小时的血糖趋势，并提供高血糖 (>= 200 mg/dl) 和低血糖 (>= 200 mg/dl)。
OBJECTIVE - Hypoglycemia and wide glucose excursions continue to be major obstacles to achieving target HbA(1c) values and the associated reductions in long-term complications (and economic costs) in people with insulin-treated diabetes. In this study we evaluated the accuracy, safety, and clinical effectiveness of a continuous glucose-sensing device.RESEARCH DESIGN AND METHODS - A total of 91 insulin-requiring patients with type 1 (n = 75) and type 2 (n = 16) diabetes were enrolled in this multicenter randomized study. Subjects wore a transcutaneous, 3-day, continuous glucose-sensing system for three consecutive 72-h periods. Subjects were randomly assigned (1:1 ratio) to either a control group (continuous glucose data not provided) or a display group (continuous glucose data not provided during period 1 but displayed during periods 2 and 3). During periods 2 and 3, patients in the display group had real-time access to sensor glucose values, could review glucose trends over the preceding 1, 3, and 9 h, and were provided with high (>= 200 mg/dl) and low (