Xylo-oligosaccharides ameliorate high cholesterol diet induced hypercholesterolemia and modulate sterol excretion and gut microbiota in hamsters
Xylo-oligosaccharides ameliorate high cholesterol diet induced hypercholesterolemia and modulate sterol excretion and gut microbiota in hamsters
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低聚木糖可改善仓鼠高胆固醇饮食引起的高胆固醇血症并调节甾醇排泄和肠道微生物群
DOI：
10.1016/j.jff.2020.104334
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发表时间：
2021-02-01
影响因子：
5.6
通讯作者：
Li, Weiwei
中科院分区：
文献类型：
--
作者：
Abdo, Abdullah Abdulaziz Abbod;Zhang, Chengnan;Li, Weiwei
本研究探讨了低聚木糖在仓鼠体内的降胆固醇活性及其相关机制。将24只仓鼠随机分为3组，分别饲喂低胆固醇饲料、高胆固醇饲料（HCD）和添加5%低聚木糖的HCD饲料6周。检查肠道微生物群、粪便中性和酸性固醇的变化。结果表明，低聚木糖能显著降低血浆总胆固醇、非高密度脂蛋白胆固醇和总三酰甘油，分别降低11.24%、24.89%和38.72%（p < 0.05）。这些益处与中性和酸性固醇以及SCFA的粪便排出量增加有关。此外，膳食补充低聚木糖可以改变肠道微生物群的组成。因此得出结论，低聚木糖补充剂可以降低血浆胆固醇水平，增强中性和酸性固醇的排泄，并通过改变肠道微生物群组成来促进SCFA的产生。
The present study investigated the cholesterol-lowering activity of xylooligosaccharides and its associated underlying mechanisms in hamsters. Twenty-four hamsters were randomly divided into three groups and fed one of three diets, namely a low cholesterol diet, a high cholesterol diet (HCD), and an HCD diet with supplementation of 5% xylo-oligosaccharides for 6 weeks. The changes in gut microbiota, fecal neutral and acidic sterols were examined. Results exhibited that xylooligosaccharides could significantly reduce plasma total cholesterol, non-high-density lipoprotein cholesterol and total triacylglycerol by 11.24%, 24.89% and 38.72%, respectively (p < 0.05). Such benefits were associated with an increase in fecal outputs of neutral and acidic sterols as well as SCFAs. Furthermore, dietary supplementation with xylo-oligosaccharides could change the composition of gut microbiota. It was therefore concluded that xylo-oligosaccharides supplementation could reduce plasma cholesterol levels, enhance the excretion of neutral and acidic sterols, and promote the production of SCFAs via changing the gut microbiota composition.