Neural Activity in Barrel Cortex Underlying Vibrissa-Based Object Localization in Mice
Neural Activity in Barrel Cortex Underlying Vibrissa-Based Object Localization in Mice
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DOI：
10.1016/j.neuron.2010.08.026
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发表时间：
2010-09-01
期刊：
影响因子：
16.2
通讯作者：
Svoboda, Karel
中科院分区：
文献类型：
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作者：
O'Connor, Daniel H.;Peron, Simon P.;Svoboda, Karel
经典研究已经将选定的新皮层神经元的尖峰与行为联系起来，但对从整个神经群体中取样的活动知之甚少。我们记录从神经元选择独立的尖峰，使用细胞附着的记录和双光子钙成像，在桶皮质的小鼠执行对象定位任务。尖峰频率在神经元之间变化，从沉默到>60 Hz。反应是多种多样的，与一些神经元表现出大的增加尖峰率时，胡须接触的对象。近一半的神经元辨别物体的位置;一小部分神经元辨别得很好。越活跃的神经元越有辨别力。层（L）4和L5含有最高比例的辨别神经元（分别为63%和79%），但少数L2/3神经元也具有高度辨别性。每个活化的桶柱约有13，000个尖峰可供小鼠决策。因此，桶状皮层中的对象位置编码是高度冗余的。
Classical studies have related the spiking of selected neocortical neurons to behavior, but little is known about activity sampled from the entire neural population. We recorded from neurons selected independent of spiking, using cell-attached recordings and two-photon calcium imaging, in the barrel cortex of mice performing an object localization task. Spike rates varied across neurons, from silence to >60 Hz. Responses were diverse, with some neurons showing large increases in spike rate when whiskers contacted the object. Nearly half the neurons discriminated object location; a small fraction of neurons discriminated perfectly. More active neurons were more discriminative. Layer (L) 4 and L5 contained the highest fractions of discriminating neurons (similar to 63% and 79%, respectively), but a few L2/3 neurons were also highly discriminating. Approximately 13,000 spikes per activated barrel column were available to mice for decision making. Coding of object location in the barrel cortex is therefore highly redundant.