Positive feedback interactions between microtubule and actin dynamics during cell motility
Positive feedback interactions between microtubule and actin dynamics during cell motility
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DOI：
10.1016/s0955-0674(99)80008-8
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发表时间：
1999-02-01
影响因子：
7.5
通讯作者：
Salmon, ED
中科院分区：
文献类型：
--
作者：
Waterman-Storer, CM;Salmon, ED
组织细胞的迁移需要微管和肌动蛋白细胞骨架系统之间的相互作用。最近的报道表明，微管与肌动蛋白动力学的相互作用在细胞中产生微管组装行为的极化，使得微管生长发生在前缘，微管缩短发生在细胞体和后部。微管的生长和缩短可以分别激活Rad和RhoA信号，以控制肌动蛋白动力学。因此，肌动蛋白依赖的梯度微管动态不稳定参数在细胞中可以反馈通过激活特定的信号通路，以延续细胞运动所需的极化肌动蛋白组装动力学。
The migration of tissue cells requires interplay between the microtubule and actin cytoskeletal systems. Recent reports suggest that interactions of microtubules with actin dynamics creates a polarization of microtubule assembly behavior in cells, such that microtubule growth occurs at the leading edge and microtubule shortening occurs at the cell body and rear. Microtubule growth and shortening may activate Rad and RhoA signaling, respectively, to control actin dynamics. Thus, an actin-dependent gradient in microtubule dynamic-instability parameters in cells may feed back through the activation of specific signalling pathways to perpetuate the polarized actin-assembly dynamics required for cell motility.