Quinolinic acid lesion of nucleus accumbens reduces D1 but not D2 dopamine receptors: an autoradiographic study.
Quinolinic acid lesion of nucleus accumbens reduces D1 but not D2 dopamine receptors: an autoradiographic study.
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伏隔核的喹啉酸损伤会减少 D1 多巴胺受体，但不会减少 D2 多巴胺受体：一项放射自显影研究。
DOI：
10.1016/0024-3205(91)90609-f
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Wamsley,JK
中科院分区：
文献类型：
--
作者：
Filloux,F;Richards,TJ;Huff,GF;Wamsley,JK
Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1receptors (as labeled by [3H]SCH 23390). Contrarily, no appreciable decrement in D2receptors (labeled by [3H]raclopride) could be identified within the same region of the NAcc. The findings support the view that accumbens D1receptors are located postsynaptically on neurons or their processes, while D2receptors within this nucleus are primarily located on afferent terminals.
