Quantitative prediction of perceptual decisions during near-threshold fear detection
Quantitative prediction of perceptual decisions during near-threshold fear detection
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DOI：
10.1073/pnas.0500566102
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发表时间：
2005-04-12
影响因子：
11.1
通讯作者：
Padmala, S
中科院分区：
文献类型：
--
作者：
Pessoa, L;Padmala, S
认知神经科学的一个基本目标是解释心理决策如何起源于基本的神经机制。本研究的目的是探讨在情绪知觉的背景下，知觉决策的神经相关。为了探讨这个问题，我们研究了功能性MRI（fMRI）信号的波动如何与近阈值恐惧检测任务中的行为选择相关。功能磁共振成像信号预测行为选择独立于刺激特性和任务准确性，在与情绪处理相关的大脑区域网络中：后扣带回皮层，内侧前额叶皮层，右额下回和左额回。我们量化了功能磁共振成像信号和行为选择之间的联系，在全脑分析中，通过信号检测理论方法确定选择概率。我们的研究结果表明，体素明智的功能磁共振成像信号可以可靠地预测行为选择的定量方式（选择概率范围从0.63至0.78）在水平上与神经元数据。我们认为，有意识的决定，一个可怕的脸已经看到了代表在一个网络的相互连接的大脑区域，准备有机体适当地处理情绪上具有挑战性的刺激，并调节相关的情绪反应。
A fundamental goal of cognitive neuroscience is to explain how mental decisions originate from basic neural mechanisms. The goal of the present study was to investigate the neural correlates of perceptual decisions in the context of emotional perception. To probe this question, we investigated how fluctuations in functional MRI (fMRI) signals were correlated with behavioral choice during a near-threshold fear detection task. fMRI signals predicted behavioral choice independently of stimulus properties and task accuracy in a network of brain regions linked to emotional processing: posterior cingulate cortex, medial prefrontal cortex, right inferior frontal gyrus, and left insula. We quantified the link between fMRI signals and behavioral choice in a whole-brain analysis by determining choice probabilities by means of signal-detection theory methods. Our results demonstrate that voxel-wise fMRI signals can reliably predict behavioral choice in a quantitative fashion (choice probabilities ranged from 0.63 to 0.78) at levels comparable to neuronal data. We suggest that the conscious decision that a fearful face has been seen is represented across a network of interconnected brain regions that prepare the organism to appropriately handle emotionally challenging stimuli and that regulate the associated emotional response.