Auditory processing in rodent models of autism: a systematic review.
Auditory processing in rodent models of autism: a systematic review.
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DOI：
10.1186/s11689-022-09458-6
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发表时间：
2022-08-30
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
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自闭症是一种复杂的疾病，具有许多特征，包括听觉敏感度的差异。人类自闭症的研究受到病因学难以控制的困扰，而对个别啮齿动物模型的研究不能代表人类自闭症的全部谱系。这篇系统的综述比较了一系列已建立的自闭症啮齿动物模型的听觉研究结果，以模拟人类种群中广泛的病因。在PubMed和Web of Science的数据库中进行了搜索，以寻找关于自闭症小鼠或大鼠模型的主要研究文章，这些文章调查了中枢听觉处理。共纳入88项研究。这些方法使用了听觉功能的非侵入性测量，例如听觉脑干反应记录、皮质事件相关电位、脑电和行为测试，这些都可以翻译成人类研究。它们还包括侵入性测量，如电生理学和组织学，这有助于了解在非侵入性研究中发现的表型的起源。在这些研究中，最一致的结果是事件相关电位N1峰的潜伏期延长，听觉皮质伽马活动的功率和一致性降低，以及对高声电平的听觉惊吓反应增加。侵袭性研究表明，皮质下抑制神经元的丧失，外侧上橄榄核和听觉丘脑的过度活动，以及听觉皮质反应的特异性降低。这篇综述比较了不同啮齿动物模型的听觉表型，并强调了那些模仿人类研究结果的模型，为未来的研究提供了一个框架和途径，以帮助了解自闭症的听觉系统。网上版载有补充材料，可在10.1186/s11689-022-09458-6查阅。
Autism is a complex condition with many traits, including differences in auditory sensitivity. Studies in human autism are plagued by the difficulty of controlling for aetiology, whereas studies in individual rodent models cannot represent the full spectrum of human autism. This systematic review compares results in auditory studies across a wide range of established rodent models of autism to mimic the wide range of aetiologies in the human population. A search was conducted in the PubMed and Web of Science databases to find primary research articles in mouse or rat models of autism which investigate central auditory processing. A total of 88 studies were included. These used non-invasive measures of auditory function, such as auditory brainstem response recordings, cortical event-related potentials, electroencephalography, and behavioural tests, which are translatable to human studies. They also included invasive measures, such as electrophysiology and histology, which shed insight on the origins of the phenotypes found in the non-invasive studies. The most consistent results across these studies were increased latency of the N1 peak of event-related potentials, decreased power and coherence of gamma activity in the auditory cortex, and increased auditory startle responses to high sound levels. Invasive studies indicated loss of subcortical inhibitory neurons, hyperactivity in the lateral superior olive and auditory thalamus, and reduced specificity of responses in the auditory cortex. This review compares the auditory phenotypes across rodent models and highlights those that mimic findings in human studies, providing a framework and avenues for future studies to inform understanding of the auditory system in autism. The online version contains supplementary material available at 10.1186/s11689-022-09458-6.
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