Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations
Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations
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DOI：
10.3390/nu11102346
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发表时间：
2019-10-01
期刊：
影响因子：
5.9
通讯作者：
Schuchardt, Jan Philipp
中科院分区：
文献类型：
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作者：
Greupner, Theresa;Koch, Elisabeth;Schuchardt, Jan Philipp
ω-3（n3）多不饱和脂肪酸（PUFA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）与健康益处相关。EPA和DHA的主要饮食来源是海鲜。α-亚油酸（ALA）尚未被证明是EPA和DHA的良好来源;然而，十八碳四烯酸（SDA）-天然包含在蓝蓟油（EO）中-可能是一个更有前途的替代品。本研究旨在研究摄入单剂量EO后的短期n3 PUFA代谢。健康年轻男性受试者（n = 12）在空腹过夜后单次摄入26 g EO。在基线和摄入EO后2、4、6、8、24、48和72 h测定血浆脂肪酸浓度和相对量。在整个检查期间，参与者接受标准化营养。单剂量EO后血浆ALA和SDA浓度迅速升高。此外，与基线相比，EPA和DPAn 3浓度在72小时后均显著增加47%; DHA浓度在72小时后也显著增加21%。总之，EO增加血浆ALA、SDA、EPA、DPAn 3和DHA浓度，可能是这些n3 PUFA的替代来源。
The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.