A transient network of intrinsically bursting starburst cells underlies the generation of retinal waves
A transient network of intrinsically bursting starburst cells underlies the generation of retinal waves
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DOI：
10.1038/nn1644
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发表时间：
2006-03-01
影响因子：
25
通讯作者：
Zhou, ZJ
中科院分区：
文献类型：
--
作者：
Zheng, JJ;Lee, S;Zhou, ZJ
药理学分离的星状无长突细胞（SAC）在围产期兔视网膜自发产生半周期性钙峰和持久的后超极化（AHPs），介导的钙激活，环AMP敏感性钾电流。这些AHPs，而不是神经递质的耗尽（如以前所认为的），产生了自发视网膜波的不应期，并设置了波频率的上限。每个SAC在一个波期间接收来自大约10-30个相邻SAC的输入。这些输入同步并重塑了内在爆发，以产生与单个SAC不同的节奏的网络振荡。随着成熟，半周期爆发在SAC消失，由于内在兴奋性降低和网络抑制增加。因此，视网膜波是由通过相互兴奋连接同步的细胞自主振荡器的瞬时且特定的网络产生的。
Pharmacologically isolated starburst amacrine cells (SACs) in perinatal rabbit retinas spontaneously generated semiperiodic calcium spikes and long-lasting after-hyperpolarizations (AHPs), mediated by calcium-activated, cyclic AMP-sensitive potassium currents. These AHPs, rather than a depletion of neurotransmitters (as was previously believed), produced the refractory period of spontaneous retinal waves and set the upper limit of the wave frequency. Each SAC received inputs from roughly 10-30 neighboring SACs during a wave. These inputs synchronized and reshaped the intrinsic bursts to produce network oscillations at a rhythm different from that of individual SACs. With maturation, the semiperiodic bursts in SACs disappeared, owing to reduced intrinsic excitability and increased network inhibition. Thus, retinal waves are generated by a transient and specific network of cell-autonomous oscillators synchronized by reciprocally excitatory connections.