Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older men.
Lack of association between androgen receptor polymorphisms and bone mineral density or physical function in older men.
复制标题
老年男性雄激素受体多态性与骨矿物质密度或身体功能之间缺乏关联。
DOI：
10.1080/07435800500406221
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发表时间：
2005
影响因子：
2.1
通讯作者：
Raisz,LG
中科院分区：
文献类型：
--
作者：
Kenny,AM;McGee,D;Joseph,C;Covault,J;Abreu,C;Raisz,LG
雄激素受体具有短聚谷氨酰胺束（由 CAG 重复序列产生）的个体可能具有更大的雄激素受体受体信号传导活性。我们评估了 91 名具有正常（对照）和低股骨颈 (FN) BMD (OP) 或有股骨骨折 (FX) 病史的老年男性的骨矿物质密度 (BMD) 和 CAG 重复之间的关联。还测量了生物可利用睾酮（BioT）和身体表现，包括综合评分（EPESE）和身体活动（PASE）。比较 FX、OP 和对照受试者，我们观察到 BMDT 分数为 22.16 6 1.08、22.26 6 0.74 和 20.20 6 0.40 (p < 0.001)； CAG 重复长度为 21.9 6 2.7、22.5 6 2.4 和 22.3 6 2.9 (p = 0.63)； BioT 水平为 2.29 6 1.25、2.19 6 1.11 和 3.99 6 1.25 nmol/L (p < 0.001)； EPESE 分数为 8.0 6 3.0、9.7 6 2.0 和 11.3 6 0.9 (p < 0.001)；和 PASE 分数分别为 91 6 66、122 6 66 和 200 6 55 (p < 0.001)。 CAG 重复次数与 BioT 或身体表现之间没有显着相关性。患有骨质疏松症或骨折的男性的 BioT、身体机能和体力活动均低于对照组。这项研究发现，在 BMD 或 FX 正常或较低的老年男性中，CAG 重复序列与 FN BMD 之间没有关联。
Individuals whose androgen receptors have short polyglutamine tracts (resulting from CAG repeats) may have greater receptor signaling activity of the androgen receptor. We evaluated the association between bone mineral density (BMD) and CAG repeats in 91 older men with normal (control) and low femoral neck (FN) BMD (OP) or a history of femoral fracture (FX). Bioavailable testosterone (BioT) and physical performance, including composite score (EPESE) and physical activity (PASE), were also measured. Comparing FX, OP, and control subjects, we observed BMDTscores of 22.16 6 1.08, 22.26 6 0.74, and 20.20 6 0.40 (p < 0.001); CAG repeat lengths of 21.9 6 2.7, 22.5 6 2.4, and 22.3 6 2.9 (p = 0.63); BioT levels of 2.29 6 1.25, 2.19 6 1.11, and 3.99 6 1.25 nmol/L (p < 0.001); EPESE scores of 8.0 6 3.0, 9.7 6 2.0, and 11.3 6 0.9 (p < 0.001); and PASE scores of 91 6 66, 122 6 66, and 200 6 55 (p < 0.001), respectively. There were no significant correlations between CAG repeats and BioT or physical performance. Men with osteoporosis or fracture had lower BioT, physical performance, and physical activity than controls. This study found no association between CAG repeats and FN BMD in older men with normal or low BMD or FX.