Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives
Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives
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DOI：
10.1016/j.tetlet.2007.07.031
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发表时间：
2007-09-03
影响因子：
1.8
通讯作者：
Cordova, Armando
中科院分区：
文献类型：
--
作者：
Ibrahem, Ismail;Rios, Ramon;Cordova, Armando
报道了醛、2-氨基壬二酸二烷基酯和α，β-不饱和醛之间高选择性的有机催化[C+NC+CC]偶联反应。该反应以良好的产率获得了高度官能化的吡咯烷衍生物，其dr> 10：1，ee为90-98%。（c）2007 Elsevier Ltd.保留所有权利。
The highly cherno- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2aminornalonates and a,p-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with > 10:1 dr and 90-98% ee. (c) 2007 Elsevier Ltd. All rights reserved.