HYALURONAN AND HYALURONECTIN IN THE EXTRACELLULAR-MATRIX OF HUMAN BRAIN-TUMOR STROMA
HYALURONAN AND HYALURONECTIN IN THE EXTRACELLULAR-MATRIX OF HUMAN BRAIN-TUMOR STROMA
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DOI：
10.1016/s0959-8049(05)80214-x
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发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
CREISSARD, P
中科院分区：
文献类型：
--
作者：
DELPECH, B;MAINGONNAT, C;CREISSARD, P
透明质酸（HA）和透明质酸结合糖蛋白透明质酸连接素（HN）在23例胶质瘤和8例脑膜瘤中进行了测定，并在35例肿瘤中重新定位。胶质母细胞瘤的HN/HA比值（<0.5）与星形细胞瘤的HN/HA比值（> 0.5）有显著性差异（P < 0.001）。HA和HN除了位于胶质瘤的细胞间部分外，还在1/3的星形细胞瘤、17/24的胶质母细胞瘤和3/7的脑膜瘤中显示出血管周围的位置，这表明它们也可以由肿瘤的血管基质产生，并且它们会阻碍新生血管的形成。所有培养的胶质瘤细胞在体外测试产生HA，而只有1/11的细胞系产生HN，在低水平。结果提示，胶质瘤HA和HN是由癌细胞和血管基质细胞共同产生的，有助于细胞外基质的形成。在脑膜瘤中，只有间质负责HA和HN的产生。
Hyaluronan (HA) and the hyaluronan-binding glycoprotein hyaluronectin (HN) were measured in 23 gliomas and 8 meningiomas and their location was revisited in 35 tumours. A clear-cut difference was found in the HN/HA ratio values of glioblastomas (below 0.5) and that of astrocytomas (above 0.5 P < 0.001). Besides their location in the intercellular part of gliomas, HA and HN displayed a perivascular location in 1/3 astrocytomas, 17/24 glioblastomas, and 3/7 meningiomas, suggesting they could be produced also by the vascular stroma of tumours and that they would characterise the neoangiogenesis. All cultivated glioma cells tested produced HA in vitro, whereas only 1/11 cell lines produced HN, at a low level. The results obtained suggest that glioma HA and HN are produced by both cancer cells and vascular stroma cells, which contribute to the edification of the extracellular matrix. In meningiomas only the stroma would be responsible for HA and HN production.