A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy
A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy
复制标题
基于黑磷的二维指纹纳米探针，用于生物 SERS 分析和化学光热治疗
作者：
Zhiming Liu;Haolin Chen;Yali Jia;Wen Zhang;Henan Zhao;Wendong Fan;Wolun Zhang;Huiqing Zhong;Yi-Rong Ni
基于黑磷（BP）的片状纳米杂化物已被开发为用于药物递送、光疗和生物成像的多功能治疗诊断纳米平台。在这项工作中，我们报告了一种简单的策略，用于制造黑磷-金纳米粒子杂化物（BP-AuNPs），它显示了非凡的近红外（NIR）光热转换效率和药物输送能力。该纳米复合物作为治疗剂用于高效化学光热肿瘤治疗的应用在体外和体内完成。BP-AuNPs在低拉曼背景的近红外激光激发下也表现出极好的表面增强拉曼散射（Sers）活性，使得BP-AuNPs被用作用于生物SERS分析的有前途的二维（2D）指纹纳米探针。基于这种类型的2D Sers基底的细胞成分鉴定和无标记活细胞生物成像得到了普遍研究，这在纳米医学中开辟了有前途的新前景，包括诊断，成像和治疗。
Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy..