TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
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DOI：
10.1016/j.eurpsy.2017.11.007
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发表时间：
2018-04-01
影响因子：
7.8
通讯作者：
Ziegler, Sibylle
中科院分区：
文献类型：
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作者：
Del Guerra, Alberto;Ahmad, Salleh;Ziegler, Sibylle
同步PET/MR/EEG（正电子发射断层扫描-磁共振-脑电图），一种新的工具，在人类大脑中的神经元网络的调查，在这里提出的欧盟项目TRIMAGE的框架内。这款三模态、经济高效的PET/MR/EEG成像工具利用了PET和MR领域的尖端技术。一种新型的磁体（1.5T，非低温）已经与PET扫描仪一起构建，该扫描仪使用最先进的光电探测器（即，SiPM矩阵）、整流器矩阵（LYSO）和数字电子。PET/MR/EEG组合系统专用于脑成像，内径为260 mm，轴向视野为160 mm。它可以同时采集和评估给定大脑中具有高空间和时间分辨率的分子代谢信息。多巴胺能系统和多巴胺能系统在精神分裂症患者进行了调查，通过PET，相同的生理/病理生理条件方面的功能连接，通过功能磁共振成像，其电生理特征，通过脑电图。除了解决神经血管-代谢耦合的基本神经科学问题外，这种新方法还为解决健康衰老、性别影响、可塑性以及不同精神和神经疾病的广泛研究领域奠定了个体生理和病理指纹的基础。成像工具（PET和MR）的两个组件的初步性能进行了讨论。合适的精神分裂症生物标志物的可能的候选人的搜索的初步结果也提出了与PET/MR系统提供的合作。(c)2017年Elsevier Masson SAS。All rights reserved.
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance - Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm.It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological conditions with regard to functional connectivity, via fMRI, and its electrophysiological signature via EEG. In addition to basic neuroscience questions addressing neurovascular-metabolic coupling, this new methodology lays the foundation for individual physiological and pathological fingerprints for a wide research field addressing healthy aging, gender effects, plasticity and different psychiatric and neurological diseases.The preliminary performances of two components of the imaging tool (PET and MR) are discussed. Initial results of the search of possible candidates for suitable schizophrenia biomarkers are also presented as obtained with PET/MR systems available to the collaboration. (c) 2017 Elsevier Masson SAS. All rights reserved.