Cell Biology: Resolving How DNA Is Damaged during 3D Migration.
Cell Biology: Resolving How DNA Is Damaged during 3D Migration.
复制标题
细胞生物学：解决 DNA 在 3D 迁移过程中如何受损的问题。
DOI：
10.1016/j.cub.2020.12.022
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Petrie,RyanJ
中科院分区：
文献类型：
--
作者：
Petrie,RyanJ
在密闭空间中迁移的细胞会受到机械应力的影响，这可能会使细胞核变形，甚至破坏核膜。一项新的研究表明，核变形足以在活跃的DNA复制部位引发双链断裂。
Cells migrating through confined spaces are subject to mechanical stresses that can deform the nucleus and even rupture the nuclear envelope. A new study reveals that nuclear deformation is sufficient to trigger double-strand breaks at sites of active DNA replication.