PROLONGED DISEASE-FREE SURVIVAL IN HODGKINS-DISEASE WITH MOPP REINDUCTION AFTER 1ST RELAPSE
PROLONGED DISEASE-FREE SURVIVAL IN HODGKINS-DISEASE WITH MOPP REINDUCTION AFTER 1ST RELAPSE
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DOI：
10.7326/0003-4819-90-5-761
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发表时间：
1979-01-01
影响因子：
39.2
通讯作者：
YOUNG, RC
中科院分区：
文献类型：
--
作者：
FISHER, RI;DEVITA, VT;YOUNG, RC
患有霍奇金病的患者 (32) 在氮芥、长春新碱、丙卡巴肼和泼尼松 (MOPP) 诱导的第一次完全缓解 [CR] 后复发，采用 MOPP 化疗进行复治。 19 名患者获得了第二次 CR。第二次 CR 的中位持续时间为 21 个月。实现第二次 CR 的可能性可以通过第一次反应的持续时间来预测。在 15 名首次 CR 持续时间超过 12 个月的患者中，有 14 名患者获得了第二次 CR，而 17 名患者中初次 CR 持续时间短于 12 个月的患者中有 5 名获得了第二次 CR。 （P<0.001）。本研究中所有接受 MOPP 再次治疗的患者的中位生存期在第一次复发后均超过 4 年。 MOPP 诱导的第一次 CR 后复发的霍奇金病患者不一定对进一步的 MOPP 治疗产生抵抗，并且可以通过 MOPP 重新诱导实现长期生存。
Patients (32) with Hodgkin''s disease who relapsed after a 1st complete remission [CR] induced by nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP) were retreated with MOPP, chemotherapy. Nineteen patients achieved a 2nd CR. Median duration of the 2nd CR was 21 mo. The likelihood of achieving a 2nd CR could be predicted by the duration of the 1st response. Of 15 patients whose 1st CR was longer than 12 mo., 14 achieved a 2nd CR in contrast to 5 of 17 patients whose initial CR lasted less than 12 mo. (P < 0.001). Median survival of all patients in this study who were re-treated with MOPP was longer than 4 yr after their 1st relapse. Patients with Hodgkin''s disease who relapse after a 1st CR induced by MOPP are not necessarily resistant to further MOPP therapy and can achieve long-term survival with MOPP reinduction.