Transport of 14C-4-cholesterol between perfusing serum and dog common carotid artery: a shear dependent process.
Transport of 14C-4-cholesterol between perfusing serum and dog common carotid artery: a shear dependent process.
复制标题
14C-4-胆固醇在灌注血清和狗颈总动脉之间的运输：剪切力依赖性过程。
作者：
C. Caro
犬颈总动脉灌注，在低透壁压，在特殊的钻机，与血清含有14 C-4-胆固醇的脂蛋白部分。动脉壁摄取标记物的幅度和空间不变性与边界层控制扩散不一致。摄取取决于壁剪切的水平，这意味着它是在血液：壁界面处的摄取过程，这是总转运中的限速步骤。
Dog common carotid arteries have been perfused, at low transmural pressure, in special rigs, with serum containing 14C-4-cholesterol in the lipoprotein moiety. The magnitude and spatial invariance of the uptake of the label by the artery wall are inconsistent with boundary layer controlled diffusion. The uptake is dependent on the level of the wall shear, implying that it is the uptake process at the blood:wall interface which is the rate-limiting step in the total transport.