Liver pathology in morbidly obese patients undergoing Roux-en-U gastric bypass surgery
Liver pathology in morbidly obese patients undergoing Roux-en-U gastric bypass surgery
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DOI：
10.1381/096089202321144577
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发表时间：
2002-02-01
期刊：
影响因子：
2.9
通讯作者：
Flancbaum, LJ
中科院分区：
文献类型：
--
作者：
Gholam, PM;Kotler, DP;Flancbaum, LJ
背景：非酒精性脂肪性肝病很常见。然而，对于病态肥胖者的肝脏疾病知之甚少。
方法：对75名在接受胃旁路术（Roux - en - Y gastric bypass surgery）时进行了术中肝脏活检的受试者（78%为女性，平均体重指数为57[范围40 - 108]）进行了研究。
结果：84%的受试者有脂肪变性，而只有约20%有中度至重度炎症和纤维化。8%有桥接纤维化或肝硬化。纤维化的存在与炎症的存在密切相关（p<...此处原文似乎不完整，可能是相关的统计值未给出>）
Background: Non-alcoholic fatty liver disease is common. However, little is known about liver disease in the morbidly obese.Methods: 75 subjects (78% female, mean BMI 57 [40-108]) who had intra-operative liver biopsies at the time of Roux-en-Y gastric bypass surgery were studied.Results: 84% of subjects had steatosis while only about 20% had moderate to severe inflammation and fibrosis. 8% had bridging fibrosis or cirrhosis. The presence of fibrosis correlated strongly with the presence of inflammation (p