Enhanced dopamine efflux in the amygdala by a predictive, but not a non-predictive, stimulus: Facilitation by prior repeated D-amphetamine
Enhanced dopamine efflux in the amygdala by a predictive, but not a non-predictive, stimulus: Facilitation by prior repeated D-amphetamine
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DOI：
10.1016/s0306-4522(98)00464-3
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发表时间：
1999-01-01
期刊：
影响因子：
3.3
通讯作者：
Phillips, GD
中科院分区：
文献类型：
--
作者：
Harmer, CJ;Phillips, GD
在致敏大鼠和未致敏对照中进行食欲巴甫洛夫调节任务期间，使用体内微透析监测杏仁核内多巴胺的细胞外水平。动物在笼子中连续 7 天接触 D-苯丙胺或媒介物（2 毫克/公斤/天，腹腔注射）。在另外七天无注射后开始训练。动物接受两种治疗类型：在调节治疗期间，在蔗糖颗粒输送之前立即施加刺激（音调或光）。在控制过程中，还提出了替代刺激，但时间上不接近其他相同的颗粒输送时间表。培训期间，每种课程类型总共有 3 个交替演示。敏化增强了对预测即将发生的颗粒输送的刺激的巴甫洛夫条件接近行为，并且对食物颗粒本身或控制刺激的接近行为没有影响。在第四次调节和控制过程中评估了杏仁核内多巴胺的细胞外水平。中杏仁核多巴胺流出在调节测试期间显着增加，但在对照期间没有显着增加，并且这种多巴胺能反应在先前重复使用过 D-安非他明的大鼠中更为明显。因此，这些结果进一步证明了杏仁核多巴胺在巴甫洛夫食欲调节中的作用，以及在先前使用过 D-安非他明后促进联想学习中的作用。 (C) 1999 国际广播组织。由爱思唯尔科学有限公司出版
Extracellular levels of dopamine within the amygdala were monitored using in vivo microdialysis during performance of an appetitive Pavlovian conditioning task in sensitized rats and unsensitized controls. Animals received exposure either to D-amphetamine or to vehicle for seven consecutive days (2 mg/kg/day, i.p.) in the home cage. Training began following a further seven injection-free days. Animals were exposed to two session types: during conditioning sessions, a stimulus (tone or light) immediately preceded sucrose pellet delivery. During control sessions, the alternative stimulus was also presented, but not in temporal proximity to an otherwise identical schedule of pellet delivery. There was a total of three alternating presentations of each session type during training. Sensitization enhanced Pavlovian conditioned approach behaviour to the stimulus predictive of imminent pellet delivery, and was without effect upon approach behaviours either to the food pellets themselves or to the control stimulus. Extracellular levels of dopamine within the amygdala were assessed during the fourth conditioning and control sessions. Mesoamygdaloid dopamine efflux increased significantly during the conditioning test session, but not during the control session, and this dopaminergic response was more marked in rats with prior repeated D-amphetamine experience.Hence, these results add to evidence suggesting a role for amygdaloid dopamine in appetitive Pavlovian conditioning, and in the facilitation of associative learning following prior experience of D-amphetamine. (C) 1999 IBRO. Published by Elsevier Science Ltd.