Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer
Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer
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DOI：
10.1002/ijc.27707
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发表时间：
2013-02-01
影响因子：
6.4
通讯作者：
Tammi, Markku
中科院分区：
文献类型：
--
作者：
Auvinen, Paivi;Tammi, Raija;Tammi, Markku
先前的体外研究表明透明质酸（HA）、CD44和HER2之间存在相互作用。我们研究了278例乳腺癌病例中HA和CD 44的表达，其中一半为HER2阳性。间质HA强染色与HER2阳性、肿瘤大、淋巴结阳性、激素受体阴性、分化差、体重指数高、复发率增加和总生存期缩短相关。在139例HER2阳性病例中，复发率与间质HA染色的强度相关，因为大多数复发发生在具有强间质HA染色的病例中。癌细胞中HA的存在与复发频率相关，因为癌细胞中没有HA的患者没有复发，而具有高百分比HA阳性癌细胞的患者中有33.3%复发。CD44阳性表达与乳腺癌低分化、绝经、三阴性有关。间质细胞中CD44阳性与HER2阳性、肿瘤大、激素受体阴性、分化差、复发率增加和总生存期缩短相关。HER2阳性与间质HA强染色之间的相关性表明，HA可能是HER2阳性患者不良结局的相关因素之一。提示乳腺癌细胞HA和间质细胞CD 44的表达可能具有临床意义。
Previous in vitro studies have suggested interactions between hyaluronan (HA), CD44 and HER2. We have studied the expression of HA and CD44 in a material of 278 breast cancer cases, half of which were HER2-positive. Intense stromal HA staining was associated with HER2 positivity, large tumor size, lymph node positivity, hormone receptor negativity, poor differentiation, a high body mass index, increased relapse rate and shortened overall survival. Among the 139 HER2-positive cases, the relapse rate was associated with the intensity of stromal HA staining as most of the relapses occurred in the cases with intense stromal HA staining. The presence of HA in the carcinoma cells was related to the frequency of relapses as none of the patients without HA in carcinoma cells experienced a relapse, whereas 33.3% of those with a high percentage of HA-positive carcinoma cells suffered a relapse. CD44 positivity in carcinoma cells was related to poor differentiation, postmenopausal status and triple negative breast carcinoma. CD44 positivity in stromal cells was associated with HER2 positivity, large tumor size, hormone receptor negativity, poor differentiation, increased relapse rate and shortened overall survival. The association between HER2 positivity and intense stromal HA staining indicates that HA could be one of the factors involved in the unfavorable outcome of HER2-positive patients. This study also suggests that HA in breast carcinoma cells and CD44 in stromal cells may have clinical significance.