Effect of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on the healing of duodenal ulcer: a double-blind multicenter study.
Effect of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on the healing of duodenal ulcer: a double-blind multicenter study.
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15(R)-15-甲基前列腺素 E2（阿巴前列素）对十二指肠溃疡愈合的影响：一项双盲多中心研究。
DOI：
10.1016/s0016-5085(82)80328-4
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发表时间：
1982
期刊：
影响因子：
29.4
通讯作者：
A. Robert
中科院分区：
文献类型：
--
作者：
G. Vantrappen;J. Janssens;T. Popiela;J. Kulig;G. Tytgat;K. Huibregtse;R. Lambert;J. Pauchard;A. Robert
对173例经内镜证实的活动性十二指肠溃疡患者（158例男性，15例女性）进行了一项多中心研究。他们以双盲方式被随机分配到两组：接受安慰剂胶囊的患者（91例患者）和接受含有100 μg 15（R）15-甲基前列腺素E2（阿巴前列腺素）胶囊的患者（82例患者）。每种药物每天摄入4次（饭前1小时和睡前），持续28天。在试验开始后第0、14和28天进行内窥镜检查。每次检查时，测量溃疡大小并记录溃疡是否愈合。阿巴前列腺素增加溃疡愈合发生率的程度与大多数西咪替丁广泛研究中报告的程度大致相同。
A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 μg of 15(R)15-methyl prostaglandin E2(arbaprostil) (82 patients). Each drug was ingested four times a day (1 h before meals and at bedtime) for 28 days. Endoscopy was performed on days 0, 14, and 28 after the trial began. At each examination, the ulcer size was measured and whether the ulcer had healed was recorded. Arbaprostil increased the incidence of ulcer healing to approximately the same degree as reported in most extensive studies with cimetidine.