Spatiotemporal Distribution Pattern of White Matter Lesion Volumes and Their Association With Regional Grey Matter Volume Reductions in Relapsing-Remitting Multiple Sclerosis
Spatiotemporal Distribution Pattern of White Matter Lesion Volumes and Their Association With Regional Grey Matter Volume Reductions in Relapsing-Remitting Multiple Sclerosis
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DOI：
10.1002/hbm.20951
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发表时间：
2010-10-01
影响因子：
4.8
通讯作者：
Borgwardt, Stefan J.
中科院分区：
文献类型：
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作者：
Bendfeldt, Kerstin;Blumhagen, Jan Ole;Borgwardt, Stefan J.
白色病变和灰质萎缩的相关性是复发缓解型多发性硬化症的一个特征。WM病变的时空分布模式，它们与区域GM变化的关系以及潜在的动力学尚不清楚。在这里，我们结合参数和非参数的基于体素的形态测量（VBM）来澄清这些问题。分析了随访12个月的进行性（PLV，n = 45）和非进行性WM病变体积（NPLV，n = 44）的RRMS患者的MRI数据。在横截面上，使用病变概率图（LPM）比较空间WM病变分布。纵向上，分别使用FSL-VBM和SPM 5-VBM研究WM病变和GM体积。WM病变聚集在侧脑室周围和半卵圆中心，PLV组的分布模式比NPLV组更广泛。两组的最大局部概率相似，T2病变（PLV：27%，NPLV：25%）的最大局部概率高于T1病变（PLV：15%，NPLV：14%）。在PLV组中，胼胝体和视放射出现了显著的WM病变变化，伴有皮质GM体积减少（P - 0.01校正），并且在额枕下束和纵束以及放射冠中进行了更自由的测试（未校正P < 0.01）。NPLV组未见WM或GM改变。在PLV组中，WM病变在纤维中的分布和发展与区域GM体积损失相关。与非进展性WM病变患者相比，进展性WM病变患者的不同时空分布模式表明发病机制的动力学差异。脑图谱31：1542- 1555，2010. (c)2010 Wiley-Liss，Inc.
The association of white matter (WM) lesions and grey matter (GM) atrophy is a feature in relapsing-remitting multiple sclerosis (RRMS). The spatiotemporal distribution pattern of WM lesions, their relations to regional GM changes and the underlying dynamics are unclear. Here we combined parametric and non-parametric voxel-based morphometry (VBM) to clarify these issues. MRI data from RRMS patients with progressive (PLV, n = 45) and non-progressive WM lesion volumes (NPLV, n - 44) followed up for 12 months were analysed. Cross-sectionally, the spatial WM lesion distribution was compared using lesion probability maps (LPMs). Longitudinally, WM lesions and GM volumes were studied using FSL-VBM and SPM5-VBM, respectively. WM lesions clustered around the lateral ventricles and in the centrum semiovale with a more widespread pattern in the PLV than in the NPLV group. The maximum local probabilities were similar in both groups and higher for T2 lesions (PLV: 27%, NPLV: 25%) than for T1 lesions (PLV: 15%, NPLV 14%). Significant WM lesion changes accompanied by cortical GM volume reductions occured in the corpus callosum and optic radiations (P - 0.01 corrected), and more liberally tested (uncorrected P < 0.01) in the inferior fronto-occipital and longitudinal fasciculi, and corona radiata in the PLV group. Not any WM or GM changes were found in the NPLV group. In the PLV group, WM lesion distribution and development in fibres, was associated with regional GM volume loss. The different spatiotemporal distribution patterns of patients with progressive compared to patients with non-progressive WM lesions suggest differences in the dynamics of pathogenesis. Hum Brain Mapp 31:1542-1555,2010. (c) 2010 Wiley-Liss, Inc.