Circulating levels of Elabela and Apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus
Circulating levels of Elabela and Apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus
复制标题
妊娠期糖尿病妊娠中期和晚期 Elabela 和 Apelin 的循环水平
DOI：
10.1080/09513590.2020.1739264
复制
发表时间：
2020-03-24
影响因子：
2
通讯作者：
Liu, Xin-Mei
中科院分区：
文献类型：
--
作者：
Guo, Yan-Yan;Li, Tong;Liu, Xin-Mei
摘要本研究旨在检测妊娠期糖尿病（GDM）妇女和非妊娠期糖尿病妇女中Elabela（ELA）和Apelin（APLN）的水平，并确定ELA、APLN和代谢参数之间是否存在任何关联。79 GDM和80名对照组受试者在孕中期和87 GDM和88名健康受试者在孕晚期。在妊娠中期，与对照组相比，GDM患者的ELA水平较低[（14.1 vs 16.9）ng/ml，p = 0.025]，APLN水平较高[（1021.8 vs 923.5）pg/ml，p = 0.046]。对照组中ELA水平与空腹血糖（FPG）呈正相关（r = 0.423，p <0.001），对照组中APLN水平与甘油三酯（TG）呈负相关（r =-0.251，p = 0.025），GDM组中总胆固醇（TC）呈负相关（r =-0.227，p = 0.044）。妊娠期ELA与糖代谢有关，而APLN与脂代谢有关。ELA的表达从孕中期到孕晚期显著下调。
Abstract We design this study to detect levels of Elabela (ELA) and Apelin (APLN) in women with and without gestational diabetes mellitus (GDM) in the second and third trimesters, and to identify whether there is any association between ELA, APLN, and metabolic parameters. Seventy-nine GDM and 80 control subjects in the second trimester and 87 GDM and 88 healthy subjects in the third trimester were included. In the second trimester, lower ELA levels [(14.1 versus 16.9) ng/ml, p = .025] and higher APLN levels [(1021.8 versus 923.5) pg/ml, p = .046] were observed in GDM patients compared to controls. ELA levels were positively correlated with fasting plasma glucose (FPG) (r = 0.423, p < .001) in the control group, and APLN levels were negatively correlated with triglycerides (TG) (r = −0.251, p = .025) in the control group and total cholesterol (TC) (r = −0.227, p = .044) in the GDM group. ELA appeared to be related to glucose metabolism and APLN is involved in lipid metabolism during pregnancy. The expression of ELA is significantly downregulated from the second trimester to the third trimester.