What do proteins need to reach different vacuoles?
What do proteins need to reach different vacuoles?
复制标题
蛋白质需要什么才能到达不同的液泡？
DOI：
10.1016/s1360-1385(99)01389-8
复制
发表时间：
1999
影响因子：
20.5
通讯作者：
N. Raikhel
中科院分区：
文献类型：
--
作者：
A. Vitale;N. Raikhel
液泡蛋白在内质网（ER）开始它们的生命，在那里它们进入分泌途径。在前肽中发现了将可溶性蛋白正确递送到液泡所需的信息，这些信息可能位于蛋白质的n端或c端，也可能位于内部。没有这些前肽，就会分泌空泡蛋白。对于膜蛋白来说，跨膜结构域和细胞质尾部都是向质体分选的重要结构域。现有的信息表明，用于溶解液泡的可溶性蛋白通过高尔基复合体运输，然后由受体进行分类，将其运送到泡前室。运往储存液泡的蛋白质可能会也可能不会穿过高尔基复合体，在被运送到储存液泡之前被包装成大而致密的囊泡。储存蛋白的分选发生在高尔基复合体或内质网本身，似乎涉及自聚集。
Vacuolar proteins begin their life in the endoplasmic reticulum (ER) where they enter the secretory pathway. The information necessary for the correct delivery of soluble proteins to vacuoles has been found in propeptides that might be located at the N-terminus or the C-terminus of the protein, or might be internal. Without these propeptides, vacuolar proteins are secreted. For membrane proteins, both the transmembrane domains and the cytosolic tails are important for sorting to the tonoplast. Available information suggests that soluble proteins destined for the lytic vacuoles are transported through the Golgi complex and then sorted by a receptor that delivers them to a prevacuolar compartment. Proteins destined for the storage vacuoles might or might not travel through the Golgi complex and are packed into large, dense vesicles before being delivered to the storage vacuoles. Sorting of storage proteins occurs along the Golgi complex or in the ER itself and appears to involve self-aggregation.
假定的液泡货物受体与拟南芥根部液泡前区室中的 AtPEP12p 部分共定位。
DOI：
10.1073/pnas.95.17.9920
发表时间：
1998
影响因子：
11.1
作者：
Sanderfoot,AA;Ahmed,SU;Marty-Mazars,D;Rapoport,I;Kirchhausen,T;Marty,F;Raikhel,NV
通讯作者：
Raikhel,NV
DOI：
10.1073/pnas.95.22.12995
发表时间：
1998-10-27
影响因子：
11.1
作者：
Jauh, GY;Fischer, AM;Rogers, JC
通讯作者：
Rogers, JC