APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES
APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES
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DOI：
10.1016/0168-3659(93)90166-3
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发表时间：
1993-05-01
影响因子：
10.8
通讯作者：
LIM, GB
中科院分区：
文献类型：
--
作者：
DEBENEDETTI, PG;TOM, JW;LIM, GB
超临界流体作为形成具有生物医学意义的颗粒的载体具有吸引力。我们回顾了两种新的技术：快速膨胀的超临界溶液形成的无溶剂，载药，可注射的微球，和气体抗溶剂沉淀过程中形成超细和生物活性的蛋白质粉末。
Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.