Asymmetric hydroformylation of vinyl acetate: Application in the synthesis of optically active isoxazolines and imidazoles
Asymmetric hydroformylation of vinyl acetate: Application in the synthesis of optically active isoxazolines and imidazoles
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DOI：
10.1021/ol070900l
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发表时间：
2007-07-05
期刊：
影响因子：
5.2
通讯作者：
Abboud, Khalil A.
中科院分区：
文献类型：
--
作者：
Thomas, P. J.;Axtell, Alex T.;Abboud, Khalil A.
(R)-和(S)-2-(乙酰氧基)-丙醛通过乙酸乙烯酯在150-180 g规模上的不对称加氢甲酰化制备[93.8% ee，(R) 102 b/l，96.9% ee，149 b/l]，并用作合成手性异恶唑啉和咪唑衍生物的起始材料，无需外消旋化手性中心。
(R)- and (S)-2-(Acetyloxy)-propanal were prepared [93.8% ee, 102 b/l for (R), 96.9% ee, 149 b/l for (S)] via asymmetric hydroformylation of vinyl acetate on a 150-180 g scale and were used as the starting materials in the synthesis of chiral isoxazoline and imidazole derivatives which proceeded without racemization of the chiral center.