CD8+ T lymphocyte counts as an adjunctive predictor of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
CD8+ T lymphocyte counts as an adjunctive predictor of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
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CD8 T 淋巴细胞计数可作为获得性免疫缺陷综合征患者巨细胞病毒性视网膜炎的辅助预测因子。
DOI：
10.2169/internalmedicine.36.461
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发表时间：
1997
影响因子：
1.2
通讯作者：
S. Kimura
中科院分区：
文献类型：
--
作者：
S. Oka;Y. Nagata;Y. Fujino;A. Yasuoka;M. Ishihara;K. Ikeda;A. Iwamoto;K. Shimada;M. Mochizuki;S. Kimura
We encountered a case of cytomegalovirus (CMV) retinitis with spontaneous regression in association with an increased number of CD8+ but not CD4+ T lymphocytes in a patient with acquired immunodeficiency syndrome (AIDS). Thus, we examined the number of CD4 and CD8 counts at the diagnosis of CMV retinitis and compared with those of Pneumocystis carinii pneumonia (PCP). All 21 patients with a confirmed diagnosis of PCP (22 episodes) and 14 CMV retinitis patients were included in this study. Although PCP occurred after depletion of CD4 count to below 200/microl, CD8 count at that time varied widely and remained normal in some patients (median: 276.5/microl, range: 133-900/microl). In contrast, as CMV retinitis occurred after further depletion of CD4 count to below 50/microl, CD8 count decreased to below 500/microl (median: 238/microl, range: 43-448/microl) (p<0.05; PCP vs CMV retinitis). The values of the sensitivity and specificity for CMV retinitis obtained at the cutoff point of either 400/microl in CD8 count and 50/microl in CD4 count were similar. When these two cutoff points were combined, the positive predictive value was 46%. Monitoring of CD8 count may prove valuable as an additional predictor of CMV retinitis in patients with AIDS after CD4 depletion.
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CD4 计数和接受抗逆转录病毒治疗的 HIV 感染患者的死亡风险。
影响因子：
39.2
作者：
Yarchoan,R;Venzon,DJ;Pluda,JM;Lietzau,J;Wyvill,KM;Tsiatis,AA;Steinberg,SM;Broder,S
通讯作者：
Broder,S
用齐多夫定消退巨细胞病毒视网膜炎。
DOI：
10.1001/archopht.1989.01070010890037
发表时间：
1989
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Guyer,DR;Jabs,DA;Brant,AM;Beschorner,WE;Green,WR
通讯作者：
Green,WR
获得性免疫缺陷综合征患者中 CD4 计数与巨细胞病毒视网膜炎和人类免疫缺陷病毒相关非感染性视网膜血管病变患病率之间的相关性。
影响因子：
4.2
作者：
Kuppermann,BD;Petty,JG;Richman,DD;Mathews,WC;Fullerton,SC;Rickman,LS;Freeman,WR
通讯作者：
Freeman,WR
影响因子：
39.2
作者：
MASUR, H;OGNIBENE, FP;LANE, HC
通讯作者：
LANE, HC