Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
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早期高脑脊液谷氨酸：动脉瘤性蛛网膜下腔出血后迟发性脑缺血的潜在预测因子
DOI：
10.1021/acsomega.0c01472
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发表时间：
2020-06
期刊：
影响因子：
4.1
通讯作者：
zong-yong Zhang
中科院分区：
文献类型：
--
作者：
Hong-bin Wang;Qing-jian Wu;Shi-jun Zhao;Ya-jun Hou;Han-xia Li;Ming-feng Yang;Bao-jun Wang;Bao-liang Sun;zong-yong Zhang
Delayed cerebral ischemia (DCI) is an important complication after aneurysmal subarachnoid hemorrhage (aSAH). Early identification of cerebrospinal fluid (CSF) markers is helpful for warning of impending DCI. This study assessed whether early high CSF glutamate levels can be observed in aSAH patients who later developed DCI. In this prospective clinical study, patients with normal pressure hydrocephalus or aSAH were enrolled. We found that the early CSF levels of glutamate were significantly elevated in aSAH patients compared to patients with normal pressure hydrocephalus. There was a significant difference in early CSF levels of glutamate between aSAH patients without DCI and with DCI. The early CSF levels of glutamate are significantly related to the Hunt and Hess grade, the World Federation of Neurological Surgeons (WFNS) grade, and the modified Fisher score on admission and occurrence of DCI in aSAH patients. Preliminary evidence of this study suggests that early high CSF glutamate levels are correlated with DCI in aSAH patients.
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DOI：
10.1146/annurev.pharmtox.011008.145533
发表时间：
2010
影响因子：
12.5
作者：
Niswender CM;Conn PJ
通讯作者：
Conn PJ
影响因子：
6.9
作者：
Fujii, Mutsumi;Yan, Junhao;Rolland, William B.;Soejima, Yoshiteru;Caner, Basak;Zhang, John H.
通讯作者：
Zhang, John H.
DOI：
10.1007/978-3-7091-6894-3_10
发表时间：
1996
期刊：
Acta neurochirurgica. Supplement
影响因子：
--
作者：
O. Nilsson;H. Säveland;F. Boris-Möller;Lennart Brandt;T. Wieloch
通讯作者：
O. Nilsson;H. Säveland;F. Boris-Möller;Lennart Brandt;T. Wieloch
影响因子：
5.5
作者：
Wang, Wen-Juan;Lu, Jing-Jing;Zhao, Xing-Quan
通讯作者：
Zhao, Xing-Quan
影响因子：
8.8
作者：
Sarrafzadeh, AS;Sakowitz, OW;Unterberg, AW
通讯作者：
Unterberg, AW