Ex vivo efficacy evaluation of laser vaporization for treatment of benign prostatic hyperplasia using a 300-W high-power laser diode with a wavelength of 980 nm.
Ex vivo efficacy evaluation of laser vaporization for treatment of benign prostatic hyperplasia using a 300-W high-power laser diode with a wavelength of 980 nm.
复制标题
使用波长 980 nm 的 300 W 高功率激光二极管进行激光汽化治疗良性前列腺增生的离体疗效评估。
DOI：
10.5978/islsm.14-or-12
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
K. Awazu
中科院分区：
文献类型：
--
作者：
Junya Takada;N. Honda;H. Hazama;K. Awazu
背景与目的
前列腺激光汽化术被认为是治疗良性前列腺增生症（BPH）的一种有前途的方法，汽化效率和止血效率都是这种治疗的重要参数。在这项研究中，我们使用了一个高功率的激光二极管与980 nm的波长，以获得高汽化效率与良好的止血。本研究的目的是在离体实验中使用波长为980 nm的300 W高功率激光二极管定量评估激光汽化治疗BPH的疗效。
材料和方法
构建了模拟临床治疗情况的离体实验装置。牛前列腺组织用作样品。功率设置为100、150、200、250或300 W，照射时间为0.5、1或2 s。激光照射后，测量汽化和凝固深度。
结果
汽化深度随激光功率和照射时间的增加而增加，结果证实了高功率半导体激光器可以有效地汽化前列腺组织。凝固深度随激光功率的增大而增大。
结论
使用波长为980 nm的高功率激光二极管对前列腺组织进行激光汽化是一种有前景的BPH治疗方法;该方法具有高汽化效率和良好的止血效果。但是，术者必须意识到内镜观察无法看到的深部凝固导致前列腺包膜术后穿孔的风险。
BACKGROUND AND OBJECTIVE
Laser vaporization of the prostate is considered to be a promising treatment for benign prostatic hyperplasia (BPH), and efficiency of vaporization and hemostasis are both important parameters for such treatment. In this study, we used a high-power laser diode with a wavelength of 980 nm to obtain high vaporization efficiency with good hemostasis. The objective of this study is to evaluate the efficacy of laser vaporization for treatment of BPH in ex vivo experiments using a 300-W high-power laser diode with a wavelength of 980 nm quantitatively.
MATERIALS AND METHODS
An ex vivo experimental setup simulating clinical treatment situation was constructed. Bovine prostate tissue was used as a sample. The power setting was 100, 150, 200, 250, or 300 W, and the irradiation time was 0.5, 1, or 2 s. After laser irradiation, vaporized and coagulated depths were measured.
RESULTS
The vaporized depth increased with the laser power and irradiation time, and the results confirmed that the high-power laser diode could efficiently vaporize the prostate tissue. Coagulated depth increased as the laser power became higher.
CONCLUSIONS
Laser vaporization of prostate tissue using a high-power laser diode with a wavelength of 980 nm represents a promising treatment for BPH; this method exhibits high vaporization efficiency and good hemostasis. However, operators must be aware of the risk of postoperative perforation of the prostatic capsule caused by coagulation of deep regions that cannot be visualized by endoscopic observation.