Does Vitamin D Provide Added Benefit to Antihypertensive Therapy in Reducing Left Ventricular Hypertrophy Determined by Cardiac Magnetic Resonance?
Does Vitamin D Provide Added Benefit to Antihypertensive Therapy in Reducing Left Ventricular Hypertrophy Determined by Cardiac Magnetic Resonance?
复制标题
维生素 D 是否可以为抗高血压治疗提供额外的益处，以减少心脏磁共振确定的左心室肥厚？
DOI：
10.1093/ajh/hpac096
复制
发表时间：
2023
影响因子：
3.2
通讯作者：
Flack,JohnM
中科院分区：
文献类型：
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作者：
Levy,PhillipD;Twiner,MichaelJ;Brody,AaronM;Dawood,Rachelle;Reed,Brian;Mango,LynnMarie;Gowland,Laura;Grandits,Greg;Svendsen,Kenneth;Haacke,EwartMark;Li,Tao;Zhang,Liying;McNaughton,CandaceD;Flack,JohnM
BACKGROUNDLeft ventricular hypertrophy (LVH) and vitamin D deficiency have been linked to hypertension (HTN) and cardiovascular disease, particularly in African Americans (AAs). Our objective was to determine if the addition of vitamin D to antihypertensive therapy would lead to greater regression of LV mass index (LVMI) as determined by cardiac magnetic resonance (CMR) after 1 year in vitamin D deficient AA patients with uncontrolled HTN and LVH.METHODSThis study was a randomized, double-blind, placebo-controlled, single-center study. AA patients with HTN (systolic blood pressure [BP] >160 mm Hg), increased LVMI, and vitamin D deficiency (<20 ng/ml) were randomized. All patients received antihypertensive therapy combined with biweekly 50,000 IU vitamin D3 (vitamin D group,n= 55) or placebo (placebo group,n= 58).RESULTSAt 1 year, there were no statistical differences between the vitamin D and placebo groups in LVMI (−14.1 ± 14.6 vs. −16.9 ± 13.1 g/m2;P= 0.34) or systolic BP (−25.6 ± 32.1 vs. −25.7 ± 25.6 mm Hg;P= 0.99) reduction, respectively. Serum vitamin D levels increased significantly in the vitamin D group compared with placebo (12.7 ± 2.0 vs. 1.8 ± 8.2 ng/ml;P< 0.001).CONCLUSIONSIn this high-risk cohort of AAs we did not find an association between vitamin D supplementation and differential regression of LVMI or reduction in systolic BP. However, our study suffered from a small sample size with low statistical power precluding a definitive conclusion on the therapeutic benefit of vitamin D in such patients.CLINICAL TRIALS REGISTRATIONTrial Number NCT01360476. Full trial protocol is available from corresponding author.
