Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
复制标题
主要精神疾病情绪感知神经系统的自发低频波动：跨频段的幅度相似性和差异
DOI：
10.1503/jpn.170226
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发表时间：
2019-03-01
影响因子：
4.3
通讯作者：
Wang, Fei
中科院分区：
文献类型：
--
作者：
Chang, Miao;Edmiston, Elliot K.;Wang, Fei
背景越来越多的证据表明精神分裂症、双相情感障碍和重性抑郁症的情感知觉既有共同的特征，又有不同的特征。在这些疾病中，自发低频波动的改变已被报道在神经系统的情绪感知，但在3种疾病的低频波动（ALFF）的幅度的相似性和差异是未知的。方法对119例精神分裂症患者、100例双相情感障碍患者、123例抑郁症患者和183名健康对照者在慢5和慢4两个频段上的情绪感知神经系统的ALFF及其信号平衡进行比较。我们进行了探索性皮尔逊偏相关分析，以确定ALFF信号平衡和临床变量之间的关系。结果3种情绪知觉障碍患者的ALFF变化模式具有共性，即大脑前部（包括皮质下、边缘、边缘和异模态皮质区）的ALFF增加，后部视皮质的ALFF减少。精神分裂症、双相情感障碍和重性抑郁障碍在慢5和慢4频段的神经系统中表现出情感知觉的ALFF信号平衡显著降低，其中精神分裂症的改变最大，其次是双相情感障碍和重性抑郁障碍。我们发现ALFF信号平衡与3种疾病中慢-4的阴性/紊乱症状之间呈负相关。我们样本中相对较宽的年龄范围和横断面研究设计可能无法解释我们的发现。结论ALFF信号平衡在精神分裂症、双相情感障碍和抑郁症的诊断和治疗中具有重要的价值。
Background Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations have been reported in the neural system for emotional perception, but the similarities and differences in the amplitude of low-frequency fluctuation (ALFF) across the 3 disorders are unknown. Methods We compared ALFF and its signal balance in the neural system for emotional perception at 2 frequency bands (slow-5 and slow-4) in 119 participants with schizophrenia, 100 with bipolar disorder, 123 with major depressive disorder and 183 healthy controls. We performed exploratory Pearson partial correlation analyses to determine the relationship between ALFF signal balance and clinical variables. Results We observed commonalities in ALFF change patterns across the 3 disorders for emotional perception neural substrates, such as increased ALFF in the anterior cerebrum (including subcortical, limbic, paralimbic and heteromodal cortical regions) and decreased ALFF in the posterior visual cortices. Schizophrenia, bipolar disorder and major depressive disorder showed significantly decreased ALFF signal balance in the neural system for emotional perception at both slow-5 and slow-4 frequency bands, with the greatest alterations for schizophrenia, followed by bipolar disorder and major depressive disorder. We found a negative correlation between ALFF signal balance and negative/disorganized symptoms in slow-4 across the 3 disorders. Limitations The relatively broad age range in our sample and the cross-sectional study design may not account for our findings. Conclusion The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder.