KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome
KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome
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DOI：
10.1038/modpathol.3800483
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发表时间：
2005-12-01
期刊：
影响因子：
7.5
通讯作者：
Vincent-Salomon, A
中科院分区：
文献类型：
--
作者：
Azoulay, S;Laé, M;Vincent-Salomon, A
最近的生物学研究将乳腺癌分为her2过表达组、雌激素受体阳性组、基础组和正常组。根据这种新的生物学分类，我们的研究目的是评估乳腺腺样囊性癌的临床、形态学和免疫表型特征，以便对这种乳腺癌亚型进行分类。共18例腺样囊性癌从居里研究所的文件被确定。有16例患者的临床信息，中位随访时间为6.5年。形态学上，所有肿瘤按照Kleer和Oberman定义的系统进行分级（组织学和核级）。用抗er、PR、HER-2、KIT、基础（CK5/6）和腔细胞角蛋白（CK8/18）和p63抗体评估免疫表型。18例肿瘤中1例为核1级（16%），9例为核2级（50%），8例为核3级（44%）。所有病例均为雌激素受体、孕激素受体和HER-2阴性。腺腔周围上皮细胞强烈阳性表达一种或两种细胞角蛋白，表明CK5/6+细胞、CK5/6和CK8/18+细胞、CK8/18+细胞和p63+细胞共存。所有病例（100%）均为KIT阳性。总共有15名患者接受了手术治疗。其中9例接受辅助放疗。随访16例。总共有14名患者存活。其中2例最初仅接受手术治疗，出现局部复发。两名患者死亡（其中一名接受放射治疗的患者仅死于她的疾病）。我们的研究表明，乳腺腺样囊性癌是一种特殊的、雌激素受体、孕激素受体、HER-2阴性和kit高度阳性的基底样乳腺癌，具有良好的预后。这种高度特异性的免疫表型可用于区分乳腺腺样囊性癌与其他亚型乳腺癌（如筛状癌）。
Recent biological studies have classified breast carcinomas into HER2-overexpressing, estrogen receptorpositive/ luminal, basal- and normal-like groups. According to this new biological classification, the objectives of our study were to assess the clinical, morphologic and immunophenotypic characteristics of adenoid cystic carcinoma of the breast in order to classify this subtype of breast carcinoma. A total of 18 cases of adenoid cystic carcinoma were identified from the Institut Curie files. Clinical information was available for 16 patients with a median follow-up of 6.5 years. Morphologically, all tumors were graded according to the system defined by Kleer and Oberman (histologic and nuclear grade). Immunophenotype was assessed with anti-ER, PR, HER-2, KIT, basal (CK5/6) and luminal cytokeratins (CK8/18) and p63 antibodies. One out of 18 tumors was nuclear grade 1 (16%), nine were nuclear grade 2 (50%) and eight were nuclear grade 3 (44%). All cases were estrogen receptor, progesterone receptor and HER-2 negative. Epithelial cells were strongly positive around glandular lumina with one or both cytokeratins, identifying the coexistence of CK5/6+ cells, CK5/6 and CK8/18+ cells, CK8/18+ cells and p63+ cells. All cases (100%) were also KIT positive. In all, 15 patients were treated by surgery. Nine of them received adjuvant radiotherapy. Follow- up was available for 16 patients. In all, 14 patients were alive. Two of them, initially treated by surgery only, presented a local recurrence. Two patients died (one of them treated by radiation therapy only died from her disease). Our study shows that adenoid cystic carcinoma of the breast is a special, estrogen receptor, progesterone receptor, HER-2 negative and highly KIT-positive, basal- like breast carcinoma, associated with an excellent prognosis. This highly specific immunophenotype could be useful to differentiate adenoid cystic carcinoma of the breast from other subtypes of breast carcinoma such as cribriform carcinoma.