Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County.
Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County.
复制标题
DOI：
10.1038/bjc.1991.210
复制
发表时间：
1991-06
影响因子：
8.8
通讯作者：
Mack TM
中科院分区：
文献类型：
--
作者：
Shimizu H;Ross RK;Bernstein L;Yatani R;Henderson BE;Mack TM
使用年龄校正的发病率和比例发病率比，在洛杉矶县本地居民中研究了三个种族/族裔群体--西班牙裔白人、其他白人和日本人--前列腺癌和乳腺癌的风险，并与移民和代表性的“祖国”人口进行了比较。开发了一种基于社会安全号码的算法，并用于估计非美国出生的洛杉矶县癌症患者的移民年龄。对于前列腺癌，洛杉矶县的发病率远远高于每个种族/民族群体的家乡。然而，无论移民时的年龄如何，移民的前列腺癌发病率与西班牙裔白色和日本人群中美国出生的患者相似。至于乳腺癌，洛杉矶县的发病率也高于家乡。然而，移民到美国的时间在确定乳腺癌风险方面很重要。当社会安全号码显示移民发生在生命后期时，乳腺癌的发病率大大低于移民发生在早期时，尽管它们仍然比祖国人口高得多。这些发现表明，早期生活中的环境因素而不是晚年生活中的环境因素在乳腺癌的病因学中很重要，并且晚年生活事件可以显著影响临床可检测的前列腺癌的可能性。
Using age-adjusted incidence rates and proportional incidence ratios, the risks of prostate cancer and breast cancer in three racial/ethnic groups - Spanish-surnamed whites, other whites and Japanese - were studied in Los Angeles County native residents and compared with those in immigrants and representative 'homeland' populations. An algorithm based on social security numbers was developed and utilised to estimate age at immigration for non-US-born Los Angeles County cancer patients. For prostate cancer, the incidence rates in Los Angeles County were much higher than those in the homelands for each racial/ethnic group. However, prostate cancer rates of immigrants were similar to those of US-born patients in the Spanish-surnamed white and Japanese populations, regardless of age at immigration. For breast cancer, the incidence rates in Los Angeles County were also high compared with those in the homelands. However, the timing of immigration to the US was important in determining breast cancer risk. When social security numbers indicated that migration occurred later in life, rates for breast cancer were substantially lower than when migration occurred early, although they were still much higher than in the homeland populations. These findings suggest that environmental factors in early life rather than in later life are important in the etiology of breast cancer and that later life events can substantially impact the likelihood of developing clinically detectable prostate cancer.