Emergence of avian H1N1 influenza viruses in pigs in China
Emergence of avian H1N1 influenza viruses in pigs in China
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DOI：
10.1128/jvi.70.11.8041-8046.1996
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发表时间：
1996-11-01
影响因子：
5.4
通讯作者：
Webster, RG
中科院分区：
文献类型：
--
作者：
Guan, Y;Shortridge, KF;Webster, RG
来自亚洲的甲型禽流感病毒被认为是基因的来源，它与人类病毒基因重新结合，在本世纪初产生了亚洲/57 （H2N2）和香港/68 （H3N2）大流行毒株。本文报道了最近从中国南方猪中分离的甲型H1N1禽流感病毒的遗传分析，该病毒被怀疑通过基因重组事件产生新的大流行毒株。8个基因片段均来自禽类。系统发育分析表明，这些基因形成欧亚鸟类谱系的亚洲亚系，表明这些病毒是独立传入亚洲猪群的。在中国的猪中存在禽流感病毒，使它们处于传播给人类的最佳位置，并可能作为下一次人类流感病毒大流行出现的早期预警。
Avian influenza A viruses from Asia are recognized as the source of genes that reasserted with human viral genes to generate the Asian/57 (H2N2) and Hong Kong/68 (H3N2) pandemic strains earlier in this century. Here we report the genetic analysis of avian influenza A H1N1 viruses recently isolated from pigs in southern China, a host suspected to generate new pandemic strains through gene reassortment events. Each of the eight gene segments was of avian origin. Phylogenetic analysis indicates that these genes form an Asian sublineage of the Eurasian avian lineage, suggesting that these viruses are an independent introduction into pigs in Asia. The presence of avian influenza viruses in pigs in China places them in an optimal position for transmission to humans and may serve as an early warning of the emergence of the next human influenza virus pandemic.