Genetic contributions to stability and change in intelligence from childhood to old age
Genetic contributions to stability and change in intelligence from childhood to old age
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DOI：
10.1038/nature10781
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发表时间：
2012-02-09
期刊：
影响因子：
64.8
通讯作者：
Visscher, Peter M.
中科院分区：
文献类型：
--
作者：
Deary, Ian J.;Yang, Jian;Visscher, Peter M.
了解健康心理衰老的决定因素是当今社会的首要任务(1,2)。到目前为止，我们知道智力差异从童年到老年表现出高度稳定性(3,4)，并且对不同年龄的遗传对智力的贡献进行了估计(5,6)。然而，试图发现遗传原因是否会导致认知衰老的差异，但信息相对较少(7-10)。在这里，我们估计了遗传和环境对人类一生大部分时间智力稳定性和变化的贡献。我们使用了来自 1,940 个无关个体的全基因组单核苷酸多态性 (SNP) 数据，这些个体的智力在童年（11 岁）和老年（65、70 或 79 岁）时进行了测量(11,12)。我们使用一种统计方法，可以根据无关个体的 SNP 数据来估计遗传（共）方差 (13-17)。我们估计，与常见 SNP 连锁不平衡的因果遗传变异占儿童期到老年认知能力变化变异的 0.24%。通过双变量分析，我们估计 11 岁时智力与老年智力之间的遗传相关性为 0.62。这些估计来自于一生认知测量的很少可用的数据，有必要寻找认知稳定性和变化的遗传原因。
Understanding the determinants of healthy mental ageing is a priority for society today(1,2). So far, we know that intelligence differences show high stability from childhood to old age(3,4) and there are estimates of the genetic contribution to intelligence at different ages(5,6). However, attempts to discover whether genetic causes contribute to differences in cognitive ageing have been relatively uninformative(7-10). Here we provide an estimate of the genetic and environmental contributions to stability and change in intelligence across most of the human lifetime. We used genome-wide single nucleotide polymorphism (SNP) data from 1,940 unrelated individuals whose intelligence was measured in childhood (age 11 years) and again in old age (age 65, 70 or 79 years)(11,12). We use a statistical method that allows genetic (co)variance to be estimated from SNP data on unrelated individuals(13-17). We estimate that causal genetic variants in linkage disequilibrium with common SNPs account for 0.24 of the variation in cognitive ability change from childhood to old age. Using bivariate analysis, we estimate a genetic correlation between intelligence at age 11 years and in old age of 0.62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change.