Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups
Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups
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DOI：
10.1021/ol052120n
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发表时间：
2005-10-27
期刊：
影响因子：
5.2
通讯作者：
Maleczka, RE
中科院分区：
文献类型：
--
作者：
Rahaim, RJ;Maleczka, RE
使用乙酸钯（11）、氟化钾水溶液和聚甲基氢硅氧烷（PMHS）的组合，可以以高产率、宽官能团耐受性和短反应时间（30 min）完成芳香族硝基到胺的室温还原。用三乙基硅烷代替PMHS/KF可将脂族硝基还原为它们的羟胺。
Room-temperature reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times (30 min) using a combination of palladium(11) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS). Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines.