Dehydrogenative Synthesis of C3-Azolylindoles via Copper-Promoted Annulative Direct Coupling of o-Alkynylanilines
Dehydrogenative Synthesis of C3-Azolylindoles via Copper-Promoted Annulative Direct Coupling of o-Alkynylanilines
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DOI：
10.1055/s-0031-1290965
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
Yoshiro Oda;Naoto Matsuyama;K. Hirano;T. Satoh;M. Miura
中科院分区：
文献类型：
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作者：
Yoshiro Oda;Naoto Matsuyama;K. Hirano;T. Satoh;M. Miura
本文报道了一种铜促进的邻炔基苯胺衍生物与1，3，4-恶二唑直接成环偶联合成C3-唑基吲哚的方法。铜基体系为从非卤化和非金属化的起始材料进行吲哚-N-恶二唑缀合物的重复构建提供了一种新的方案。
A copper-promoted annulative direct coupling of o -alkynylaniline derivatives with 1,3,4-oxadiazoles for the synthesis of C3-azolylindoles has been developed. The copper-based system provides a new protocol for the dehydrogenative construction of indole–oxadiazole conjugations from nonhalogenated and nonmetalated starting materials.