Infection of dendritic cells by murine cytomegalovirus induces functional paralysis
Infection of dendritic cells by murine cytomegalovirus induces functional paralysis
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DOI：
10.1038/ni724
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发表时间：
2001-11-01
影响因子：
30.5
通讯作者：
Degli-Esposti, MA
中科院分区：
文献类型：
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作者：
Andrews, DM;Andoniou, CE;Degli-Esposti, MA
巨细胞病毒 (CMV)、麻疹和 HIV 是已知可引起免疫抑制的主要人类病原体。与麻疹和艾滋病毒不同，尽管有经过充分研究的动物模型，但人们对控制 CMV 诱导的免疫抑制的机制知之甚少。我们假设树突状细胞（DC）对于产生和维持免疫反应至关重要，是 CMV 的靶标，并且 CMV 感染伴随的短暂但深刻的免疫抑制是病毒干扰 DC 功能的结果。在这里，我们表明 DC 允许小鼠 CMV 感染。此外，DC 感染阻止了 T 细胞激活所需信号的传递。因此，CMV 介导的 DC 功能损伤可能对于病毒诱导的免疫抑制至关重要，而白细胞介素 2 是一个关键因素。
Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.