The antimicrobial and osteoinductive properties of silver nanoparticle/poly(DL-lactic-co-glycolic acid)-coated stainless steel
The antimicrobial and osteoinductive properties of silver nanoparticle/poly(DL-lactic-co-glycolic acid)-coated stainless steel
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DOI：
10.1016/j.biomaterials.2012.08.010
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发表时间：
2012-12-01
期刊：
影响因子：
14
通讯作者：
Soo, Chia
中科院分区：
文献类型：
--
作者：
Liu, Yi;Zheng, Zhong;Soo, Chia
植入物相关细菌感染是骨科手术中最严重的并发症之一。这些感染的治疗通常需要多次手术、器械取出、长期全身性抗生素和长期康复，并且通常无效，导致临床结果更差和财务成本增加。在这项研究中，我们评估了银纳米颗粒/聚（DL-乳酸-羟基乙酸共聚物）（PLGA）涂层不锈钢合金（SNPSA）作为潜在的抗菌植入材料。结果表明，SNPSA具有较强的体外抗菌活性，并能促进MC 3 T3-E1前成骨细胞的增殖和成熟。此外，SNPSA植入物诱导成骨，同时抑制细菌在受污染的大鼠股骨管内的存活。我们的研究结果表明，SNPSA同时具有抗菌和骨诱导性能，使其成为骨科手术中有前途的治疗材料。爱思唯尔有限公司出版
Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery. Published by Elsevier Ltd.