Lineage relationship and protective immunity of memory CD8 T cell subsets
Lineage relationship and protective immunity of memory CD8 T cell subsets
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DOI：
10.1038/ni889
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发表时间：
2003-03-01
影响因子：
30.5
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Wherry, EJ;Teichgräber, V;Ahmed, R
记忆性CD 8 T细胞可以分为两个亚群，中央（T-CM）和效应（T-EM），但它们的谱系关系和它们持续存在并赋予保护性免疫的能力还不清楚。我们的研究结果表明，T-CM有一个更大的能力比T-EM坚持在体内，更有效地介导的保护性免疫，因为它们的增殖潜力增加。我们还表明，抗原清除后，T-EM转换为T-CM，这种分化的持续时间是在免疫后的第一周内编程。我们认为，T-CM和T-EM不一定代表不同的子集，但在线性幼稚效应--> T-EM --> T-CM分化途径中是连续体的一部分。
Memory CD8 T cells can be divided into two subsets, central (T-CM) and effector (T-EM), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T-CM have a greater capacity than T-EM to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T-EM convert to T-CM and that the duration of this differentiation is programmed within the first week after immunization. We propose that T-CM and T-EM do not necessarily represent distinct subsets, but are part of a continuum in a linear naive effector --> T-EM --> T-CM differentiation pathway.