Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging
Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging
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DOI：
10.1523/jneurosci.1083-07.2007
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发表时间：
2007-07-11
影响因子：
5.3
通讯作者：
Viola, Haydee
中科院分区：
文献类型：
--
作者：
Moncada, Diego;Viola, Haydee
突触标记和捕获过程是突触可塑性的一个关键特性，最近已经预测了一种行为模拟。在这里，我们证明，弱抑制性回避训练，诱导短期，但不是长期记忆（LTM），可以巩固到LTM的探索一个新的，但不是一个熟悉的，发生在时间接近的培训课程的环境。这种由新奇引起的记忆促进效应依赖于多巴胺D-1/D-5受体的激活，并需要背海马中新合成的蛋白质。因此，我们的研究结果表明，存在一个行为标记过程中，一个新的环境的探索提供了可塑性相关的蛋白质，以稳定抑制性回避记忆痕迹。
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memory-promoting effect caused by novelty depends on activation of dopamine D-1/D-5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace.