Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project.
Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project.
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DOI：
10.1289/ehp.7387
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发表时间：
2005-01
影响因子：
10.4
通讯作者：
Katsouyanni, Klea
中科院分区：
文献类型：
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作者：
Samoli, Evangelia;Analitis, Antonis;Touloumi, Giota;Schwartz, Joel;Anderson, Hugh R;Sunyer, Jordi;Bisanti, Luigi;Zmirou, Denis;Vonk, Judith M;Pekkanen, Juha;Goodman, Pat;Paldy, Anna;Schindler, Christian;Katsouyanni, Klea
有几项研究报告了空气污染对健康的重大影响，即使在低水平的空气污染物，但在大多数这些研究中，线性非阈值关系假设。我们调查了参与APHEA（空气污染与健康-欧洲方法）项目的22个欧洲城市的环境颗粒物与死亡率之间的安全响应关系，该项目是欧洲最大的数据库。我们使用带有两个节点的回归样条模型估计了风险-响应曲线，然后结合样条的各个城市估计值，得到总体风险-响应关系。为了进一步探索所观察到的城市特定的风险-反应关联的异质性，我们研究了几个城市描述性变量作为可能改变曲线形状的潜在效应修饰符。我们的结论是，包括在本分析中的城市，并在所有分析的城市中常见的污染物的范围内，环境颗粒物和死亡率之间的关联，可以充分估计使用的线性模型。我们的研究结果证实了以前在欧洲和美国报道的结果。在不同的城市特定的关系中发现的异质性反映了真实的影响修改，这可以部分解释为空气污染混合，气候和人口健康的特征因素。
Several studies have reported significant health effects of air pollution even at low levels of air pollutants, but in most of theses studies linear nonthreshold relations were assumed. We investigated the exposure–response association between ambient particles and mortality in the 22 European cities participating in the APHEA (Air Pollution and Health—A European Approach) project, which is the largest available European database. We estimated the exposure–response curves using regression spline models with two knots and then combined the individual city estimates of the spline to get an overall exposure–response relationship. To further explore the heterogeneity in the observed city-specific exposure–response associations, we investigated several city descriptive variables as potential effect modifiers that could alter the shape of the curve. We conclude that the association between ambient particles and mortality in the cities included in the present analysis, and in the range of the pollutant common in all analyzed cities, could be adequately estimated using the linear model. Our results confirm those previously reported in Europe and the United States. The heterogeneity found in the different city-specific relations reflects real effect modification, which can be explained partly by factors characterizing the air pollution mix, climate, and the health of the population.