An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory
An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory
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DOI：
10.1096/fj.13-234823
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发表时间：
2013-10-01
期刊：
影响因子：
4.8
通讯作者：
Fowden, Abigail L.
中科院分区：
文献类型：
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作者：
Sferruzzi-Perri, Amanda N.;Vaughan, Owen R.;Fowden, Abigail L.
在发达国家，高糖高脂(HSHF)饮食现在是常态，并正在增加怀孕期间母亲肥胖率。在怀孕的啮齿动物中，这些饮食会导致成年后代的心血管和代谢功能障碍，但其中涉及的宫内机制尚不清楚。这项研究表明，与标准饲料相比，在小鼠怀孕期间喂食HSHF会增加母亲的肥胖率(+30%，P
In developed societies, high-sugar and high-fat (HSHF) diets are now the norm and are increasing the rates of maternal obesity during pregnancy. In pregnant rodents, these diets lead to cardiovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involved remain unknown. This study shows that, relative to standard chow, HSHF feeding throughout mouse pregnancy increases maternal adiposity (+30%, P