Vitamin A functions in the regulation of the dopaminergic system in the brain and pituitary gland.
Vitamin A functions in the regulation of the dopaminergic system in the brain and pituitary gland.
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维生素 A 具有调节大脑和垂体多巴胺能系统的功能。
DOI：
10.1111/j.1753-4887.1998.tb01678.x
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发表时间：
2009
影响因子：
6.1
通讯作者：
G. Wolf
中科院分区：
文献类型：
--
作者：
G. Wolf
视黄酸与其受体结合，通过调节多巴胺受体D2R的表达在大脑和脑垂体中发挥作用，D2R是多巴胺能系统的一个组成部分。配体维甲酸受体是D2R完全表达所必需的特异性转录因子。d2r基因敲除小鼠缺乏这些视黄酸受体，并表现出与帕金森病相似的运动能力缺陷。
Retinoic acids, bound to their receptors, function in the brain and pituitary gland by regulating the expression of the dopamine receptor D2R, which is a component of the dopaminergic system. The liganded retinoic acid receptors are specific transcription factors that are essential for full expression of D2R. D2R-knockout mice lack these retinoic acid receptors and exhibit a defect in locomotor ability similar to that seen in Parkinson's disease.
DOI：
10.1073/pnas.87.11.4265
发表时间：
1990-06-01
影响因子：
11.1
作者：
MACDONALD, PN;BOK, D;ONG, DE
通讯作者：
ONG, DE