Recurrent intracranial germinoma along the endoscopic ventriculostomy tract. Case report.
Recurrent intracranial germinoma along the endoscopic ventriculostomy tract. Case report.
复制标题
沿内镜脑室造口道复发性颅内生殖细胞瘤。
作者：
Ung Choi;S. Cha;G. Song;C. Choi;Sang Weon Lee;Y. Lim;Won Kim
作者报告了一例经三维适形放射治疗完全局部控制肿瘤后，沿内窥镜第三脑室造口术(ETV)部位复发的颅内生殖细胞瘤。1例13岁女孩突然出现左上注视受限，持续4天。磁共振(MR)检查发现松果体区肿瘤和梗阻性脑积水。进行了ETV和肿瘤活检，发现病变是生殖细胞瘤。术后患者的视觉症状和脑积水消失。术后第10天开始使用顺铂、依托泊苷、长春新碱和环磷酰胺进行化疗。术后10周和化疗后2周的MR图像显示病变明显减少(>；50%)。靶区放射治疗剂量为50.4GY，周边照射剂量为36Gy.手术后10个月，核磁共振图像显示肿瘤进一步缩小。术后一年，随访的MR成像显示ETV入口处有一小块肿块，大小为1.0x1.4x1.5 cm。手术切除了小病灶，病理结果显示它与原发肿瘤具有相同的组织学特征。
The authors report a case of a recurrent intracranial germinoma along the site of an endoscopic third ventriculostomy (ETV) after complete local tumor control using 3D conformal radiation therapy. A 13-year-old girl presented with sudden left upward gaze limitation for 4 days. A pineal region tumor and obstructive hydrocephalus were noted on magnetic resonance (MR) images. An ETV and tumor biopsy procedure were performed, which revealed the lesion to be a germinoma. The patient's visual symptoms and hydrocephalus disappeared postoperatively. Chemotherapy using cisplatin, etoposide, vincristine, and cyclophosphamide was initiated on postoperative Day 10. An MR image obtained 10 weeks after surgery and 2 weeks after chemotherapy revealed a significant (> 50%) reduction of the lesion. Radiation therapy was administered at 50.4 Gy to the target and 36 Gy to the periphery. Ten months after surgery, an MR image revealed further shrinkage of the tumor mass. One year after surgery, follow-up MR imaging demonstrated a small mass lesion at the entry site of the ETV, measuring 1.0 x 1.4 x 1.5 cm. An operation was performed to remove the small lesion, and pathological findings revealed it to be of the same histology as the primary tumor.
DOI：
10.1016/s0360-3016(99)00375-2
发表时间：
2000-03-15
影响因子：
7
作者：
Merchant, TE;Sherwood, SH;Kun, LE
通讯作者：
Kun, LE